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crossalive

crossalive

CROSSalive predicts RNA secondary structure profiles considering chemical modifications occurring in the cell. In the current implementation, CROSSalive predicts m6A and A-to-I effects on transcripts at single nucleotide resolution.



 

Submission reference: 916838


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Calculate RNA Structural Profile:

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Expert mode (with protein contribution)


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in vivo m6a (+)
in vivo m6a (-)
in vivo A-to-I (+)
in vivo A-to-I (-)


Select model:

in vivo m6a (+)
in vivo m6a (-)


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RNA Sequences (FASTA format, please ensure that your sequences only contain A, C, G, T, and U. Do not use !@#$% etc.; the minimum required sequence length is 70 nucleotides)


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Sample data

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m6A example on Xist RepC - Profile of the RepC, a region of Xist mildly affected by METLL3, showing a Pearson’s correlation of 0.30 with in vivo SHAPE data (Smola et al. 2016)
A-to-I example on NEAT1 - Profile of the whole sequence of NEAT1, a lincRNA whose structural profile was studied in presence of ADAR showing a AUC of 0.85 with PARS data (Solomon et al. 2017)